UMC St Radboud Nijmegen - General Internal Medicine

Internal Medicine, General

The department of General Internal Medicine is a large tertiairy care facility with a substantial and diverse involvement in the academic missions of patient care, teaching and research. The department is formally divided in three sections. The research of each section is closely connected to its specific patient groups .

We perform research in de following areas:

Infectious diseases, host defense and inflammation embedded In the Nijmegen Institute for Infection, Inflammation and Immunity (N4i).
Vascular Medicine (atherosclerosis and hypertension), embedded in Nijmegen Centre for Evidence Based Practice (NCEBP) and research Institute for Genetic and Metabolic Disease (IGMD).
Diabetes and metabolism, embedded in the IGMD

The research inspired by observations at the bedside, is carried out in the Laboratory of Experimental Internal Medicine and the Clinical Physiology and Pharmacology Unit of our department. A major aim is to translate the findings of this research back to the clinical arena to the benefit of the patient.

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About 20 years ago Paul Smits and Jacques Lenders introduced the forearm model in our laboratory. The brachial artery is cannulated to infuse adenosine or other drugs of interest. Forearm blood flow is measured using mercury-in-silastic strain-gauge plethysmography.

The hand circulation is occluded to exclude skin circulation as much as possible from the experimental preparation. Blood flow is measured at both forearms simultaneously to detect systemic actions and to control for non-specific random changes in flow that occur for example due to mental arousal or inactivity.

Forearm blood flow is calculated from the velocity of change in forearm volume that occurs during rapid inflations of the upper arm cuffs at supravenous pressures.

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